PARK7 protein translocating into spermatozoa mitochondria in Chinese asthenozoospermia
نویسندگان
چکیده
منابع مشابه
Ultrastructural changes and asthenozoospermia in murine spermatozoa lacking the ribosomal protein L29/HIP gene
or Hets and WT (Table 1) for testicular weights, a measure of total sperm production. However, in analyses of a minimum of 200 sperm per animal, gross motility (80% reduced) and progressive motility (91% reduced) were significantly (P < 0.001; Table 1) impaired in null sperm, compared to WT. The Het sperm showed 35% and 32% decrease (P < 0.001) in gross and progressive motility (P < 0.001), com...
متن کاملProtein import into mitochondria.
Most mitochondrial proteins are encoded by the nuclear genome and thus have to be imported into mitochondria from the cytosol. Protein translocation across and into the mitochondrial membranes is a multistep process facilitated by the coordinated action of at least four specialized translocation systems in the outer and inner membranes of mitochondria. The outer membrane contains one general tr...
متن کاملMechanisms of Protein Import into Mitochondria Review
Apart from a handful of proteins encoded by the mitochondrial genome, most proteins residing in this organelle are nuclear-encoded and synthesised in the cytosol. Thus, delivery of proteins to their final destination depends on a network of specialised import components that form at least four main translocation complexes. The import machinery ensures that proteins earmarked for the mitochondri...
متن کاملMechanisms of Protein Import into Mitochondria
Apart from a handful of proteins encoded by the mitochondrial genome, most proteins residing in this organelle are nuclear-encoded and synthesised in the cytosol. Thus, delivery of proteins to their final destination depends on a network of specialised import components that form at least four main translocation complexes. The import machinery ensures that proteins earmarked for the mitochondri...
متن کاملChloride channels are involved in sperm motility and are downregulated in spermatozoa from patients with asthenozoospermia
Human spermatozoa encounter an osmotic decrease from 330 to 290 mOsm l-1 when passing through the female reproductive tract. We aimed to evaluate the role of chloride channels in volume regulation and sperm motility from patients with asthenozoospermia. Spermatozoa were purified using Percoll density gradients. Sperm volume was measured as the forward scatter signal using flow cytometry. Sperm ...
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ژورنال
عنوان ژورنال: REPRODUCTION
سال: 2014
ISSN: 1470-1626,1741-7899
DOI: 10.1530/rep-14-0222